This is a Spine forum, so of course the answer you will get here is to use Spine. π
Except for creating the art, Adobe CC doesn't help much unless you want to do frame-by-frame animation. Spine has many advantages over frame-by-frame, shown in the first demo here and described here.
For very simple animations, you can animate them in Unity directly. For anything more complex, I expect you'll find Spine both more powerful and easier to use. Spine is a dedicated tool for 2D animation, while Unity's animation tools are tacked on to a giant game toolkit. Most importantly, Spine's features are designed specifically for doing 2D animation in games. Spine makes editing skeletons and animations easy and the runtime architecture is flexible and has the features needed to build games.
Spine also has a great online forum. π