This is a Spine forum, so of course the answer you will get here is to use Spine.

Except for creating the art, Adobe CC doesn't help much unless you want to do frame-by-frame animation. Spine has many advantages over frame-by-frame, shown in the first demo here and described here.

For very simple animations, you can animate them in Unity directly. For anything more complex, I expect you'll find Spine both more powerful and easier to use. Spine is a dedicated tool for 2D animation, while Unity's animation tools are tacked on to a giant game toolkit. Most importantly, Spine's features are designed specifically for doing 2D animation in games. Spine makes editing skeletons and animations easy and the runtime architecture is flexible and has the features needed to build games.

Spine also has a great online forum.

The topic starter was a spammer, so their question is gone. They copy/paste questions from other parts of the internet, then edit them later to add links. I hate it because they waste our time giving support. I spent all the time writing a response though, so I left my post.

Yeah, I don't know why they think that is a good idea. It's real people creating an account and spending the effort to copy/paste nonsense. The trouble will really be when the spammers start using AI and are indistinguishable from real users, right up until they try to post/edit links. I suppose we can solve that by only giving support to users with a Spine license. That sucks for people in the evaluation phase, but I don't think there's a better solution.