When you say it doesn't work, I guess you mean the Spine launcher window appears, you choose eg
Latest 4.0, the launcher disappears, and then the Spine editor window never appears?
From the log it looks like everything is working. The hotkeys file error in the log is just because you've run 4.1-beta. It won't affect the Spine window showing.
Do you have multiple monitors? Could you try running Spine with just one monitor? If you have a laptop, try without any monitors, just the laptop screen.
Have you installed any new software recently? Anything related to monitors, screen sharing, or similar?